IMMUNHISTOCHEMICAL EXPRESSION OF ESTROGEN, PROGESTERON RECEPTORS, C-ERB B-2, P53 AND BRCA1 IN OVARIAN CARCINOMA AND THEIR PROGNOSTIC VALUE

Our study aimed to determine immunohistochemical expression of ER, PR, C-erbB-2, p53 and BRCA1 genes their relationship with clinicopathological features prognostic significance. The present included 85 patients that were diagnosed epithelial OC, treated followed-up between 2002 2012 at Mersin University, Faculty Medicine. Immunohistochemical relation-ship parameters evaluated. In serous carcinomas, ER was significantly associated metastasis the fallopian tube, PR patient’s age, progression-free survival (PFS), cytoplasmic overall (OS) PFS. pathogenesis groups, 55 tumors type 1, 30 2. There significant correlations expressions two groups. our study, factors in carcinoma. Extensive studies contain more cases each histological group are needed value these five markers.